Left untreated, alpha-1 antitrypsin deficiency can seriously, even fatally, damage the liver and lungs. This program enables viewers to understand the incurable disorder and how it can be identified and treated. Computer-generated animation shows how AAT, a protein that facilitates lung function, can back up in the liver and never reach the lungs. Three case studies, including one featuring a lung transplant patient, help to explain AATD’s causes, symptoms, and lifestyle impact while outlining protein augmentation therapy and oxygen supplementation. Dr. Kyle Hogarth of the University of Chicago Medical Center and John Walsh, founder of the Alpha 1 Foundation, are featured in interviews. (25 minutes)