This detailed overview examines migraines, cluster headaches, and tension headaches from a neurobiological perspective. Headache experts Fred Sheftell, of the American Council for Headache Education; Stephen Silberstein, of Thomas Jefferson University’s headache clinic; Jack Gladstein, of the University of Maryland’s children’s hospital; Peter Goadsby, of the Institute of Neurology, London; and Harvard University’s Mike Cutrer reveal the results of their research while explaining phenomena such as headache triggers, drug-induced rebound, and migraine auras. In addition, several patients—female and male, adolescent and adult—talk about their efforts to find relief. Not available in French-speaking Canada. A Discovery Channel Production. (46 minutes)