This insightful program, narrated by George Strait, raises viewer awareness of how patients cope with the day-to-day pain, uncertainty, and stigma of sickle-cell disease through the cases of two African-Americans—pop singer T-Boz, spokesperson for the American Sickle Cell Association, and Infinity, a 4-year-old girl—and a 9-year-old Latina named Nina. Current research and experimental treatments are presented by Surgeon General David Satcher; national sickle-cell expert Lakshmanan Krishnamurti; John Wagner, head of gene therapy at the University of Minnesota; Griffin Rodgers, of the NIH; and others. A Discovery Channel Production. (46 minutes)